Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading.

ABSTRACT:

Objective

Temporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role of estrogen in the disease etiology. Previously, we determined that decreased occlusal loading (DOL) inhibited collagen type II (Col2) expression in the mandibular condylar cartilage (MCC) of female wild-type (WT) mice whereas no change was observed in males. This decrease in chondrogenesis was abolished by estrogen receptor beta (ERβ) deficiency in females. Therefore, the goal of this study was to examine the role of estradiol - ERβ signaling in mediating DOL effects in male mice to further decipher sex differences.

Methods

Male 21 day-old WT and ERβKO male mice were treated with either placebo or estradiol and exposed to normal or DOL for 4 weeks. Cartilage thickness and cell pr

SUBMITTER: Robinson JL 

PROVIDER: S-EPMC5359071 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature