Monomorphic genotypes within a generalist lineage of Campylobacter jejuni show signs of global dispersion.

ABSTRACT: The decreased costs of genome sequencing have increased the capability to apply whole-genome sequencing to epidemiological surveillance of zoonotic Campylobacter jejuni. However, knowledge of the genetic diversity of this bacteria is vital for inferring relatedness between epidemiologically linked isolates and a necessary prerequisite for correct application of this methodology. To address this issue in C. jejuni we investigated the spatial and temporal signals in the genomes of a major clonal complex and generalist lineage, ST-45 CC, by analysing the population structure and genealogy as well as applying genome-wide association analysis of 340 isolates from across Europe collected over a wide time range. The occurrence and strength of the geographical signal varied between s

SUBMITTER: Llarena AK 

PROVIDER: S-EPMC5359405 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature