MTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.

ABSTRACT: The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the direct role of this complex in osteoblast biology remains to be determined. To investigate this question, we disrupted mTORC1 function in preosteoblasts by targeted deletion of Raptor (Rptor) in Osterix-expressing cells. Deletion of Rptor resulted in reduced limb length that was associated with smaller epiphyseal growth plates in the postnatal skeleton. Rptor deletion caused a marked reduction in pre- and postnatal bone accrual, which was evident in skeletal elements derived from both intramembranous and endochondrial ossification. The decrease in bone accrual, as well as the associated increase in skeletal fragility, was due to a reduction in osteoblast functi

SUBMITTER: Fitter S 

PROVIDER: S-EPMC5359426 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature