Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.

ABSTRACT:

Background

Expression of host microRNAs (miRNAs) changes markedly during influenza A virus (IAV) infection of natural and adaptive hosts, but their role in genetically determined host susceptibility to IAV infection has not been explored. We, therefore, compared pulmonary miRNA expression during IAV infection in two inbred mouse strains with differential susceptibility to IAV infection.

Results

miRNA expression profiles were determined in lungs of the more susceptible strain DBA/2J and the less susceptible strain C57BL/6J within 120 h post infection (hpi) with IAV (H1N1) PR8. Even the miRNomes of uninfected lungs differed substantially between the two strains. After a period of relative quiescence, major miRNome reprogramming was detected in both strains by 48 hpi and increa

SUBMITTER: Preusse M 

PROVIDER: S-EPMC5359533 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature