Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: a systematic review.

ABSTRACT:

Introduction

HIV infection is associated with vascular dysfunction and adverse cardiovascular outcomes. Our objective was to review the evidence regarding the clinical utility of endothelial activation and coagulation biomarkers for the prognosis of HIV-infected patients.

Methods

We searched PubMed and Embase for publications using the keywords "HIV" or "HIV infection" and "endothelium" or "coagulation". We reviewed reference lists and hand-searched for additional relevant articles. All clinical studies that enrolled non-pregnant, HIV-infected adults, measured biomarkers reflecting endothelial activation or coagulation, and prospectively evaluated their associations with vascular dysfunction or clinical outcomes were included.

Results

Seventeen studies were identified

SUBMITTER: Graham SM 

PROVIDER: S-EPMC5359730 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature