Tryptophan-rich domains of Plasmodium falciparum SURFIN_4.2 and Plasmodium vivax PvSTP2 interact with membrane skeleton of red blood cell.

ABSTRACT:

Background

Plasmodium falciparum dramatically alters the morphology and properties of the infected red blood cells (iRBCs). A large group of exported proteins participate in these parasite-host interactions occurring at the iRBC membrane skeleton. SURFIN_4.2 is one of iRBC surface protein that belongs to surface-associated interspersed protein (SURFIN) family. Although the intracellular tryptophan-rich domain (WRD) was proposed to be important for the translocation of SURFINs from Maurer's clefts to iRBC surface, the molecular basis of this observation has yet to be defined. The WRDs of P. falciparum SURFIN proteins and their orthologous Plasmodium vivax subtelomeric transmembrane proteins (PvSTPs) show homology to the intracellular regions of PfEMP1 and Pf332, both of wh

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5359885 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature