Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals.

ABSTRACT:

Background

Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals-termed viremic non-progressors (VNP) or controllers-do not seem to progress to AIDS, maintaining high CD4⁺ T cell counts despite high levels of viremia for many years. Several studies have evaluated multiple host factors, including immune activation, trying to elucidate the atypical HIV-1 disease progression in these patients; however, limited work has been done to characterize viral factors in viremic controllers.

Methods

We analyzed HIV-1 isolates from three VNP individuals and compared the replicative fitness, near full-length HIV-1 genomes and intra-patient HIV-1 genetic diversity with virus

SUBMITTER: Weber J 

PROVIDER: S-EPMC5359922 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature