Correlated duplications and losses in the evolution of palmitoylation writer and eraser families.

ABSTRACT:

Background

Protein post-translational modifications (PTMs) change protein properties. Each PTM type is associated with domain families that apply the modification (writers), remove the modification (erasers) and bind to the modified sites (readers) together called toolkit domains. The evolutionary origin and diversification remains largely understudied, except for tyrosine phosphorylation. Protein palmitoylation entails the addition of a palmitoyl fatty acid to a cysteine residue. This PTM functions as a membrane anchor and is involved in a range of cellular processes. One writer family and two erasers families are known for protein palmitoylation.

Results

In this work we unravel the evolutionary history of these writer and eraser families. We constructed a high-quality prof

SUBMITTER: Wittouck S 

PROVIDER: S-EPMC5359973 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature