Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.

ABSTRACT:

Background

Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the different pancreatic cell types has been maintained during vertebrate evolution, the comparison of their transcriptomes across distant vertebrate species is a means to pinpoint genes under strong evolutionary constraints due to their crucial function, which have therefore preserved their selective expression in these pancreatic cell types.

Results

In this study, RNA-sequencing was performed on pancreatic alpha, beta, and delta endocrine cells as well as the acinar and ductal exocrine cells isolated from adult zebrafish transgenic lines. Comparison of these tra

SUBMITTER: Tarifeno-Saldivia E 

PROVIDER: S-EPMC5360028 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature