Weekly response assessment of involved lymph nodes to radiotherapy using diffusion-weighted MRI in oropharynx squamous cell carcinoma.

ABSTRACT:

Purpose

Patients with cancers of oropharynx have a favorable prognosis and are an ideal candidate for adaptive therapy. A replan to improve coverage or escalate/de-escalate dose based on morphological information alone may not be adequate as the grossly involved lymph nodes (LNs) of a subset of these patients tend to become cystic and often do not regress. Functional adaptation may be a better approach when considering replanning for these patients. The purpose of this study was to evaluate the weekly trends in treatment related morphological and physiological changes for these LNs using diffusion-weighted MRI (DW-MRI) and evaluate its implications for adaptive replanning.

Methods

Ten patients with histologically proven oropharynx HNSCC undergoing concurrent chemoradiation w

SUBMITTER: Tyagi N 

PROVIDER: S-EPMC5360161 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature