Biological and pathophysiological roles of end-products of DHA oxidation.

ABSTRACT:

Background

Polyunsaturated fatty acids (PUFA) are known to be present and/or enriched in vegetable and fish oils. Among fatty acids, n-3 PUFA are generally considered to be protective in inflammation-related diseases. The guidelines for substituting saturated fatty acids for PUFAs have been highly publicized for decades by numerous health organizations. Recently, however, the beneficial properties of n-3 PUFA are questioned by detailed analyses of multiple randomized controlled clinical trials. The reported heterogeneity of results is likely due not only to differential effects of PUFAs on various pathological processes in humans, but also to the wide spectrum of PUFA's derived products generated in vivo.

Scope of review

The goal of this review is to discuss the studies focu

SUBMITTER: Yakubenko VP 

PROVIDER: S-EPMC5360178 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature