Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

ABSTRACT:

Background

Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction.

Methods and findings

Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5). We then integrated these AD-associated SNPs into a Cox proportional hazard model using genotype data from a subset of 6,409 AD patients and 9,386 older controls from Phase 1 of the Alzheimer's Disease Genetics Consortium (ADGC), providing a polygenic hazard score (PHS) for each participant. By

SUBMITTER: Desikan RS 

PROVIDER: S-EPMC5360219 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature