Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study.

ABSTRACT:

Background

The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters with atherosclerosis are limited. Here, we assessed that relation.

Methods

Individual participant data from 14 cohorts, involving 59,025 individuals were used in this cross-sectional analysis. We made 15 clusters of four risk factors (current smoking, overweight, elevated blood pressure, elevated total cholesterol). Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) between clusters using those without any of the four risk factors as reference group.

Results</

SUBMITTER: Wang X 

PROVIDER: S-EPMC5360240 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature