Insulin and bone health in young adults: The mediator role of lean mass.

ABSTRACT:

Background

The positive relationship between lean mass (LM) and bone health is well known, but a positive association between insulin and LM has also been described. Insulin has some anabolic properties on bone through the stimulation of osteoblast differentiation, yet the role of LM as a confounder or mediator in this relationship remains uncertain.

Objective

To examine whether the association between insulin levels and bone health is mediated by LM.

Methods

A cross-sectional study was conducted at the Castilla La Mancha University (Spain) involving 466 young adults (113 young men; 19.5±2.3 years). LM and total-body bone mineral content (BMC) were measured by dual energy x-ray absorptiometry, and insulin was measured in fasting serum samples.

Results

Young adu

SUBMITTER: Torres-Costoso A 

PROVIDER: S-EPMC5360249 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature