HCV coinfection contributes to HIV pathogenesis by increasing immune exhaustion in CD8 T-cells.

ABSTRACT:

Background

There are several contributors to HIV-pathogenesis or insufficient control of the infection. However, whether HIV/HCV-coinfected population exhibits worst evolution of HIV-pathogenesis remains unclear. Recently, some markers of immune exhaustion have been proposed as preferentially upregulated on T-cells during HIV-infection. Herein, we have analyzed T-cell exhaustion together with several other contributors to HIV-pathogenesis that could be affected by HCV-coinfection.

Patients and methods

Ninety-six patients with chronic HIV-infection (60 HIV-monoinfected and 36 HIV/HCV-coinfected), and 20 healthy controls were included in the study. All patients were untreated for both infections. Several CD4 and CD8 T-cell subsets involved in HIV-pathogenesis were investigated

SUBMITTER: Rallon N 

PROVIDER: S-EPMC5360268 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature