Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study.

ABSTRACT:

Objective

Aortic stiffness is an important predictor of future morbidity and mortality. Diabetes is associated with increased aortic stiffness, but the importance of nondiabetic glucometabolic status for accelerated aortic stiffening is unclear. We tested the hypothesis that adverse glucometabolic status is associated with accelerated aortic stiffening in individuals without diabetes, independently of known risk factors for arterial stiffening.

Research design and methods

Glucometabolic status and other cardiovascular risk factors were assessed at baseline in 2008-09, and carotid femoral pulse wave velocity (cfPWV) at baseline and follow-up in 2012-13, in 4,386 participants without diabetes of the Whitehall II Study.

Results

The mean age of the cohort at cfPWV baselin

SUBMITTER: McEniery CM 

PROVIDER: S-EPMC5360278 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature