Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines.

ABSTRACT:

Background

Despite recent advances in treatment strategies, it is still difficult to cure patients with hepatocellular carcinoma (HCC). Sorafenib is the only approved multiple kinase inhibitor for systemic chemotherapy in patients with advanced HCC. The majority of advanced HCC patients are resistant to sorafenib. The mechanisms of sorafenib resistance are still unknown.

Methods

The expression of molecules involved in the mitogen-activated protein kinase (MAPK) signaling pathway in human hepatoma cell lines was examined in the presence or absence of sorafenib. Apoptosis of human hepatoma cells treated with sorafenib was investigated, and the expression of Jun proto-oncogene (c-Jun) was measured.

Results

The expression and phosphorylation of c-Jun were enhanced in huma

SUBMITTER: Haga Y 

PROVIDER: S-EPMC5360329 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature