DMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.

ABSTRACT: In the nervous system, glial cells provide crucial insulation and trophic support to neurons and are important for neuronal survival. In reaction to a wide variety of insults, glial cells respond with changes in cell morphology and metabolism to allow repair. Additionally, these cells can acquire migratory and proliferative potential. In particular, after axonal damage or pruning the clearance of axonal debris by glial cells is key for a healthy nervous system. Thus, bidirectional neuron-glial interactions are crucial in development, but little is known about the cellular sensors and signalling pathways involved. In here, we show that decreased cellular fitness in retinal progenitors caused by reduced Drosophila Myc expression triggers non cell-autonomous activation of retinal glia prolife

SUBMITTER: Tavares L 

PROVIDER: S-EPMC5360344 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature