Palatability of a novel oral formulation of prednisone in healthy young adults.

ABSTRACT:

Objectives

Prednisone is a widely used anti-inflammatory for a variety of conditions. While oral liquid formulations of prednisone enable weight-based dosing, children frequently find them to be objectionable due to bitter taste. This limitation of prednisone can adversely impact patient acceptance and may result in non-compliance. Efforts to mask flavours often result in poorly controlled, heterogeneous particle distributions and can provide ineffective taste masking. The present work utilized a novel drug delivery technology developed by Orbis Biosciences, Inc., to create an oral taste-masked formulation of prednisone.

Methods

The study examined the palatability of Orbis' microsphere prednisone formulation in healthy young adults (n = 24). Four test articles were used in t

SUBMITTER: Bai S 

PROVIDER: S-EPMC5360468 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature