Virus-Specific CD8⁺ T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression.

ABSTRACT: It is well known that CD8⁺ tumor-infiltrating lymphocytes (TILs) are correlated with positive prognoses in cancer patients and are used to determine the efficacy of immune therapies. Although it is generally assumed that CD8⁺ TILs will be tumor-associated Ag (TAA) specific, it is unknown whether CD8⁺ T cells with specificity for common pathogens also infiltrate tumors. If so, the presence of these T cells could alter the interpretation of prognostic and diagnostic TIL assays. We compared TAA-specific and virus-specific CD8⁺ T cells in the same tumors using murine CMV, a herpesvirus that causes a persistent/latent infection, and vaccinia virus, a poxvirus that is cleared by the host. Virus-specific CD8⁺ TILs migrated into cutaneous mela

SUBMITTER: Erkes DA 

PROVIDER: S-EPMC5360480 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature