Differential mutation frequencies in metastatic cutaneous squamous cell carcinomas versus primary tumors.

ABSTRACT:

Background

Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one of the most highly mutated cancers but typically is associated with low rates of metastasis and high survival rates. Nevertheless, metastatic cSCC is a significant health threat; up to 8800 individuals die each year of this disease.

Methods

Because it is difficult to predict which cSCCs are more likely to metastasize, and because to the best of the authors' knowledge there are no targeted therapies specifically designated for patients with metastatic cSCC, exome and/or targeted sequencing of 18 metastatic and 10 primary cSCCs was performed to identify mutations that were more frequent in metastatic tumors an

SUBMITTER: Yilmaz AS 

PROVIDER: S-EPMC5360561 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature