Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.

ABSTRACT: Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects experimentally challenged with influenza A/H3N2 or human rhinovirus, and to develop targeted assays measuring peptides involved in this host response allowing classification of acute respiratory virus infection. Unbiased proteomic discovery analysis identified 3285 peptides corresponding to 438 unique proteins, and revealed that infection with H3N2 induces significant alterations in protein expression. These include proteins involved in acute inflammatory response, innate immune response, and the complement cascade. These data provide insights into the nature of the biolog

SUBMITTER: Burke TW 

PROVIDER: S-EPMC5360578 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature