Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents.

ABSTRACT: Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional ('hot') and cognitive control ('cold') neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-fro

SUBMITTER: Chattopadhyay S 

PROVIDER: S-EPMC5360581 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature