Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus.

ABSTRACT:

Objective

We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE.

Methods

436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (±3.9) years later. Fifty-six individuals transitioned to SLE (≥4 cumulative American College of Rheumatology criteria). 25-Hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single-nucleotide polymorphisms in four vitamin D genes were genotyped. Generalised estimating equations, adjusting for correlation within families, were used to test associations between the vitamin D variables and the outcome of transitioning to SLE.

Results

Mean baseline 25[OH

SUBMITTER: Young KA 

PROVIDER: S-EPMC5360632 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature