Simulating Longitudinal Brain MRIs with Known Volume Changes and Realistic Variations in Image Intensity.

ABSTRACT: This paper presents a simulator tool that can simulate large databases of visually realistic longitudinal MRIs with known volume changes. The simulator is based on a previously proposed biophysical model of brain deformation due to atrophy in AD. In this work, we propose a novel way of reproducing realistic intensity variation in longitudinal brain MRIs, which is inspired by an approach used for the generation of synthetic cardiac sequence images. This approach combines a deformation field obtained from the biophysical model with a deformation field obtained by a non-rigid registration of two images. The combined deformation field is then used to simulate a new image with specified atrophy from the first image, but with the intensity characteristics of the second image. This allows to gene

SUBMITTER: Khanal B 

PROVIDER: S-EPMC5360759 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature