Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.

ABSTRACT:

Background

The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

Objective

Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females.

Methods

The review was conducted according to a previously published protocol. Three reviewers independently selected relevant studies from the search results, extracted data, assessed the risk of bias, and rated the quality of the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results</

SUBMITTER: Layton AM 

PROVIDER: S-EPMC5360829 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature