PXL01 in sodium hyaluronate results in increased PRG4 expression: a potential mechanism for anti-adhesion.

ABSTRACT:

Purpose

To investigate the anti-adhesive mechanisms of PXL01 in sodium hyaluronate (HA) by using the rabbit lactoferrin peptide, rabPXL01 in HA, in a rabbit model of healing tendons and tendon sheaths. The mechanism of action for PXL01 in HA is interesting since a recent clinical study of the human lactoferrin peptide PXL01 in HA administered around repaired tendons in the hand showed improved digit mobility.

Materials and methods

On days 1, 3, and 6 after tendon injury and surgical repair, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to assess mRNA expression levels for genes encoding the mucinous glycoprotein PRG4 (also called lubricin) and a subset of matrix proteins, cytokines, and growth factors involved in flexor tendon repair. RabPXL

SUBMITTER: Edsfeldt S 

PROVIDER: S-EPMC5361429 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature