Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.

ABSTRACT:

Purpose

The large Forkhead (Fox) transcription factor family has essential roles in development, and mutations cause a wide range of ocular and nonocular disease. One member, Foxc2 is expressed in neural crest (NC)-derived periocular mesenchymal cells of the developing murine eye; however, its precise role in the development, establishment, and maintenance of the ocular surface has yet to be investigated.

Methods

To specifically delete Foxc2 from NC-derived cells, conditional knockout mice for Foxc2 (NC-Foxc2-/-) were generated by crossing Foxc2F mice with Wnt1-Cre mice. Similarly, we also generated compound NC-specific mutations of Foxc2 and a closely related gene, Foxc1 (NC-Foxc1-/-;NC-Foxc2-/-) in mice.

Results

Neural crest-Foxc2-/- mice show abnormal thickness in

SUBMITTER: Seo S 

PROVIDER: S-EPMC5361455 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature