Adaptive Diversification Between Yellow Fever Virus West African and South American Lineages: A Genome-Wide Study.

ABSTRACT: Yellow fever virus (YFV) has emerged as the causative agent of a vector-borne disease with devastating mortality in the tropics of Africa and the Americas. YFV phylogenies indicate that the isolates collected from West Africa, East and Central Africa, and South America cluster into different lineages and the virus spread into the Americas from Africa. To determine the nature of genetic variation accompanying the intercontinental epidemic, we performed a genome-wide evolutionary study on the West African and South American lineages of YFV. Our results reveal that adaptive genetic diversification has occurred on viral nonstructural protein 5 (NS5), which is crucially required for viral genome replication, in the early epidemic phase of these currently circulating lineages. Furthermore, major

SUBMITTER: Li Y 

PROVIDER: S-EPMC5361553 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature