Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.

ABSTRACT:

Purpose

Enhanced regeneration of retinal ganglion cell (RGC) axons can be achieved by modification of numerous neuronal-intrinsic factors. However, axon growth initiation and the pathfinding behavior of these axons after traumatic injury remain poorly understood outside of acute injury paradigms, despite the clinical relevance of more chronic settings. We therefore examined RGC axon regeneration following therapeutic delivery that is postponed until 2 months after optic nerve crush injury.

Methods

Optic nerve regeneration was induced by virally mediated (adeno-associated virus) ciliary neurotrophic factor (AAV-CNTF) administered either immediately or 56 days after optic nerve crush in wild-type or Bax knockout (KO) mice. Retinal ganglion nerve axon regeneration was assessed

SUBMITTER: Yungher BJ 

PROVIDER: S-EPMC5361588 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature