Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.

ABSTRACT: Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline. We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women's Health Initiative, as well as 402 male and female participants from the Italian cohort study, Invecchiare nel Chianti.Extrinsic epigenetic age acceleration (EEAA) exhibits significant associations with fish intake (p=0.02), moderate alcohol consumption (p=0.01), education (p=3x10^-5), BMI (p=0.01), and blood carotenoid level

SUBMITTER: Quach A 

PROVIDER: S-EPMC5361673 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature