CDKN2A/p16INK4^a expression is associated with vascular progeria in chronic kidney disease.

ABSTRACT: Patients with chronic kidney disease (CKD) display a progeric vascular phenotype linked to apoptosis, cellular senescence and osteogenic transformation. This has proven intractable to modelling appropriately in model organisms. We have therefore investigated this directly in man, using for the first time validated cellular biomarkers of ageing (CDKN2A/p16^INK4a, SA-β-Gal) in arterial biopsies from 61 CKD patients undergoing living donor renal transplantation. We demonstrate that in the uremic milieu, increased arterial expression of CDKN2A/p16^INK4a associated with vascular progeria in CKD, independently of chronological age. The arterial expression of CDKN2A/p16^INK4a was significantly higher in patients with coronary calcification (p=0.0

SUBMITTER: Stenvinkel P 

PROVIDER: S-EPMC5361677 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature