Will bevacizumab biosimilars impact the value of systemic therapy in gynecologic cancers?

ABSTRACT:

Objective

Bevacizumab is an important component in the treatment of various cancers, and despite guidelines recommending its use in both ovarian and cervical cancer, patient access to bevacizumab and other angiogenesis inhibitors is limited. Biosimilars are large, structurally complex molecules that are intended to be highly similar to, and treat the same condition(s) as, an existing licensed or approved (reference) biologic, with no clinically meaningful differences in purity, potency and safety. This article summarizes the role of bevacizumab in the treatment paradigm of ovarian and cervical cancer. We also discuss the potential role of biosimilars to bevacizumab, which may offer more affordable options in the future treatment of gynecologic cancers.

Methods

Literature sea

SUBMITTER: Monk BJ 

PROVIDER: S-EPMC5361700 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature