A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.

ABSTRACT: It is well established that the gene expression patterns are substantially altered in cardiac hypertrophy and heart failure, however, less is known about the reasons behind such global differences. MicroRNAs (miRNAs) are short non-coding RNAs that can target multiple molecules to regulate wide array of proteins in diverse pathways. The goal of the study was to profile alterations in miRNA expression using end-stage human heart failure samples with an aim to build signaling network pathways using predicted targets for the altered miRNA and to determine nodal molecules regulating individual networks. Profiling of miRNAs using custom designed microarray and validation with an independent set of samples identified eight miRNAs that are altered in human heart failure including one novel miRNA y

SUBMITTER: Naga Prasad SV 

PROVIDER: S-EPMC5362047 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature