Tissue factor pathway inhibitor for prediction of placenta-mediated adverse pregnancy outcomes in high-risk women: AngioPred study.

ABSTRACT:

Objective

The study aimed to evaluate if the rate of tissue factor pathway inhibitor during pregnancy and following delivery could be a predictive factor for placenta-mediated adverse pregnancy outcomes in high-risk women.

Methods

This was a prospective multicentre cohort study of 200 patients at a high risk of occurrence or recurrence of placenta-mediated adverse pregnancy outcomes conducted between June 2008 and October 2010. Measurements of tissue factor pathway inhibitor resistance (normalized ratio) and tissue factor pathway inhibitor activity were performed for the last 72 patients at 20, 24, 28, 32, and 36 weeks of gestation and during the postpartum period.

Results

Overall, 15 patients presented a placenta-mediated adverse pregnancy outcome. There was no diffe

SUBMITTER: Di Bartolomeo A 

PROVIDER: S-EPMC5362074 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature