Peripheral blood metabolic and inflammatory factors as biomarkers to ocular findings in diabetic macular edema.

ABSTRACT:

Aims

To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients.

Material and methods

Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal t

SUBMITTER: Figueras-Roca M 

PROVIDER: S-EPMC5362077 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature