Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection.

ABSTRACT:

Background

Scrub typhus, a febrile illness of substantial incidence and mortality, is caused by infection with the obligately intracellular bacterium Orientia tsutsugamushi. It is estimated that there are more than one million cases annually transmitted by the parasitic larval stage of trombiculid mites in the Asia-Pacific region. The antigenic and genetic diversity of the multiple strains of O. tsutsugamushi hinders the advancement of laboratory diagnosis, development of long-lasting vaccine-induced protection, and interpretation of clinical infection. Despite the life-threatening severity of the illness in hundreds of thousands of cases annually, 85-93% of patients survive, often without anti-rickettsial treatment. To more completely understand the disease caused by Orientia infe

SUBMITTER: Mendell NL 

PROVIDER: S-EPMC5362142 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature