The effect of early versus late initiation of renal replacement therapy in patients with acute kidney injury: A meta-analysis with trial sequential analysis of randomized controlled trials.

ABSTRACT:

Background

The optimal timing for initiating renal replacement therapy (RRT) in patients with acute kidney injury (AKI) remains controversial.

Methods

We conducted a meta-analysis with trial sequential analysis (TSA) of randomized controlled trials (RCTs) using PUBMED, Cochrane Library databases, and Web of Science (from January 1, 1985, to August 21, 2016). Adult patients with AKI who received RRT with different timing were included. The primary outcome was mortality. The secondary outcomes were intensive care unit (ICU) length of stay (LOS) and hospital LOS.

Results

We included 9 RCTs with a total of 1636 participants. No differences between the early RRT group and the late RRT group were found with respect to mortality (38% vs 41.4%; relative risk, 0.93; 95% confid

SUBMITTER: Feng YM 

PROVIDER: S-EPMC5362192 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature