EP4 receptor promotes invadopodia and invasion in human breast cancer.

ABSTRACT: The production of Prostaglandin E₂ (PGE₂) is elevated in human breast cancer cells. The abnormal expression of COX-2, which is involved in the synthesis of PGE₂, was recently reported as a critical determinant for invasiveness of human breast cancer cells. Autocrine and paracrine PGE₂-mediated stimulation of the PGE₂ receptor EP4 transduces multiple signaling pathways leading to diverse patho-physiological effects, including tumor cell invasion and metastasis. It is known that PGE₂-induced EP4 activation can transactivate the intracellular signaling pathway of the epidermal growth factor receptor (EGFR). In malignant cancer cells, EGFR pathway activation promotes invadopodia protrusions, which further leads to degradation of

SUBMITTER: Tonisen F 

PROVIDER: S-EPMC5362301 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature