Ontology highlight
ABSTRACT:
SUBMITTER: Shen F
PROVIDER: S-EPMC5362419 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Oncotarget 20170201 9
Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and cancer progression. However, the expression and function of SPRY4-IT1 in the progression of CRC remains largely unknown. Here, we reported that SPRY4-IT1 was upregulated in CRC. Increased SPRY4-IT1 expression in CRC was associated with larger tumor size and higher clinical stage. In vitro experim ...[more]