Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer.

ABSTRACT: Radiotherapy combined with platinum-based chemotherapy is the standard-of-care of locally advanced cervical cancer (CC) patients, while nearly 50% of patients do not respond to standard chemotherapy. Thus, identification of relative molecules participated in chemotherapy might provide new insights in the treatment of CC. In this study, we found a cohort of miRNAs were dysregulated upon treatment with cisplatin, among of which miR-29b was the most upregulated one. We further detected its expression in CC tissues, and found that miR-29b was significantly suppressed in CC and its precancerous lesions, HSIL tissues, and was negatively related with tumor invasion. However, upon treatment with cisplatin, the expression of miR-29b was significantly up-regulated. The biological function assays sho

SUBMITTER: Li Y 

PROVIDER: S-EPMC5362433 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature