Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma.

ABSTRACT:

Background and purpose

A previous study demonstrated that GALNT10 affects the sensitivity of cancer cells to tyrosine kinase inhibitor (TKI) therapy. The aim of this study was to assess whether GALNT10 holds a prognostic role in metastatic renal cell carcinoma (mRCC) patients treated with TKI agents.

Results

GALNT10 had no statistical correlation with any other clinicopathological parameters except for route of gaining samples (P = 0.001) and Heng's risk stratification (P = 0.011). Patients with high level of GALNT10 had significantly shorter overall survival (OS) (P < 0.001) and progression-free survival (PFS) (P = 0.002). Importantly, this relationship existed in OS and PFS analyses in sunitinib-treated patients and in OS analyses in sorafenib-treated patients (P = 0.024).

SUBMITTER: Liu L 

PROVIDER: S-EPMC5362461 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature