SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer.

ABSTRACT: Non-muscle invasive bladder cancer has a high recurrence rate of 45-70%, progressing to muscle invasive disease in about 15% of those patients over a 5-year period. Administration of the mycobacterium, Bacillus Calmette-Guerin (BCG) that induces local inflammation resulting in tumor remission in responsive patients is frequently used for treatment. BCG-treated patients with NF-κB del/del genotype have an increased risk of recurrence suggesting an important role of NF-κB in bladder cancer. Since protein methyltransferases play critical roles in modulating chromatin structure and gene expression, we screened a focused array of epigenetic modification genes to identify differential expression between normal urothelial and bladder cancer cells. We found and validated high expression of the SET

SUBMITTER: Mukherjee N 

PROVIDER: S-EPMC5362471 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature