Probing the prostate tumour microenvironment II: Impact of hypoxia on a cell model of prostate cancer progression.

ABSTRACT: Approximately one in six men are diagnosed with Prostate Cancer every year in the Western world. Although it can be well managed and non-life threatening in the early stages, over time many patients cease to respond to treatment and develop castrate resistant prostate cancer (CRPC). CRPC represents a clinically challenging and lethal form of prostate cancer. Progression of CRPC is, in part, driven by the ability of cancer cells to alter their metabolic profile during the course of tumourgenesis and metastasis so that they can survive in oxygen and nutrient-poor environments and even withstand treatment. This work was carried out as a continuation of a study aimed towards gaining greater mechanistic understanding of how conditions within the tumour microenvironment impact on both androgen s

SUBMITTER: Tonry C 

PROVIDER: S-EPMC5362488 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature