Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice.

ABSTRACT: RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1^f/fSos2^-/- mice to CD4-Cre transgenic mice. We previously reported an effect of these mutations on T cell signaling and T cell migration. Unexpectedly, we observed nodules on the joints of greater than 90% of these mutant mice at 5 months of age, especially on the carpal joints. As the mice aged further, some also displayed joint stiffness, hind limb paralysis, and lameness. Histological analysis indicated that the abnormal growth in joints originated from dysplastic chondrocytes. Second harmonic generation imaging of the carpal nodules revealed that nodules were encased by rich collagen fi

SUBMITTER: Guittard G 

PROVIDER: S-EPMC5362643 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature