Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases.

ABSTRACT:

Introduction

Antibiotics are the most commonly prescribed drug class in children. Real-world data mining on the paediatric population showed potential associations between antibiotic use and acute liver injury.

Objective

We assessed risk estimates of liver injury associated with antibiotic use in children and adolescent outpatients.

Methods

A large, multi-database, population-based, case-control study was performed in people <18 years of age from two European countries (Italy and The Netherlands) during the period 2000-2008. All potential cases of liver injury were automatically extracted from three databases and then manually validated based on Council for International Organizations of Medical Sciences (CIOMS) criteria and by exclusion of all competing causes for li

SUBMITTER: Ferrajolo C 

PROVIDER: S-EPMC5362651 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature