Phase III Soft Tissue Sarcoma Trials: Success or Failure?

ABSTRACT:

Opinion statement

Two recently reported phase III randomised control trials (RCTs) have resulted in the registration of two new systemic therapies for advanced soft tissue sarcoma. Both of these trials' designs were informed by phase II data that guided the selection of sensitive STS diagnoses, enabling the demonstration of benefit in certain subtypes. A number of other phase III trials reported in the last 18 months have seemingly fit into a recurrent pattern of failure-promising efficacy signals in earlier phase studies being lost in the survival follow-up of large, highly heterogeneous cohorts. Greater effort is needed to identify histological and molecularly defined subgroups associated with differential treatment response in order to avoid the tremendous disappointment and los

SUBMITTER: Lee AT 

PROVIDER: S-EPMC5362672 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature