Calmodulin is responsible for Ca²⁺-dependent regulation of TRPA1 Channels.

ABSTRACT: TRPA1 is a Ca²⁺-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca²⁺, with low Ca²⁺ potentiating and high Ca²⁺ inactivating TRPA1. However, it remains unknown how Ca²⁺ exerts such contrasting effects. Here, we show that Ca²⁺ regulates TRPA1 through calmodulin, which binds to TRPA1 in a Ca²⁺-dependent manner. Calmodulin binding enhanced TRPA1 sensitivity and Ca²⁺-evoked potentiation of TRPA1 at low Ca²⁺, but inhibited TRPA1 sensitivity and promoted TRPA1 desensitization at high Ca²⁺. Ca²⁺-dependent potentiation and inactivation of TRPA1 were selectively prevented by disrupting the intera

SUBMITTER: Hasan R 

PROVIDER: S-EPMC5362816 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature