Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein.

ABSTRACT: MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to >25 countries since 2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) in the Arabian Peninsula highlight the ongoing public health threat of this virus. Therefore, development of effective prophylactic vaccine needs to be urgently explored given that there are no approved prophylactics or therapeutics for humans or animals to date. Different vaccine candidates have been investigated but serious safety concerns remain over protein or full-length spike (S) protein-based vaccines. Here, we investigated the immunogenicity of naked DNA vaccines expressing different fragments of MERS-CoV S protein in mice. We found that plasmids expressing full-length (pS) or S1-subunit (pS1) could indu

SUBMITTER: Al-Amri SS 

PROVIDER: S-EPMC5362948 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature