The Arabidopsis miR396 mediates pathogen-associated molecular pattern-triggered immune responses against fungal pathogens.

ABSTRACT: MicroRNAs (miRNAs) play a pivotal role in regulating gene expression during plant development. Although a substantial fraction of plant miRNAs has proven responsive to pathogen infection, their role in disease resistance remains largely unknown, especially during fungal infections. In this study, we screened Arabidopsis thaliana lines in which miRNA activity has been reduced using artificial miRNA target mimics (MIM lines) for their response to fungal pathogens. Reduced activity of miR396 (MIM396 plants) was found to confer broad resistance to necrotrophic and hemibiotrophic fungal pathogens. MiR396 levels gradually decreased during fungal infection, thus, enabling its GRF (GROWTH-REGULATING FACTOR) transcription factor target genes to trigger host reprogramming. Pathogen resistance in MIM

SUBMITTER: Soto-Suarez M 

PROVIDER: S-EPMC5362962 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature